Refractory Immune Checkpoint Inhibitor Colitis successfully managed with Tacrolimus

Immune Checkpoint Inhibitor related colitis (“irColitis”) can range in severity from mild symptoms that may self resole with supportive therapy, to life-threatening disease. More severe cases require immunosuppression corticosteroids or biologic therapies, but there is little evidence about what do when these agents fail. In this article we present a case of irColitis was refractory established pharmacological treatments, then resolved after introduction Tacrolimus. Successful treatment Tacrolimus has not previously been reported and so finding will be significant for future research studies guidelines.